Which is a quinoline alkaloid?
Quinoline alkaloids such as quinine, quinidine, cinchonine, and cinchonidine (Fig. 4.8) were the first drugs developed to treat malaria and come from Cinchona officinalis and related Cinchona species (Rubiaceae) which naturally occur in Central and South America.
What is the function of quinoline?
Quinoline is used principally for the manufacture of nicotinic acid, which prevents pellagra in humans, and other chemicals. Several methods are known for its preparation, and production of synthetic quinoline exceeds that from coal tar.
Which drug contains Quinazoline alkaloids?
Quinine and camptothecin are two of the most famous and important quinoline alkaloids, and their discoveries opened new areas in antimalarial and anticancer drug development, respectively.
What is quinoline?
Quinoline is used in the manufacture of dyes, the preparation of hydroxyquinoline sulfate and niacin. It is also used as a solvent for resins and terpenes. Quinoline is mainly used as in the production of other specialty chemicals.
Which of the following is the example of proto alkaloids?
1.2. Protoalkaloids are those with a closed ring, being perfect but structurally simple alkaloids. They form a minority of all alkaloids. Hordenine, mescaline (Figure 1.5), and yohimbine are good examples of these kinds of alkaloid.
What is quinazoline ring?
Quinazoline is an organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid that is soluble in water.
What are quinazoline derivatives?
Derivatives of quinazolines constitute a large group of chemicals with a wide range of biological properties, and many quinazoline derivatives are approved for antitumor clinical use, e.g.,: erlotinib, gefitinib, afatinib, lapatinib, and vandetanib.
Are quinolone and quinoline the same thing?
Quinoline antimalarials are one of the most common drugs used in clinical treatment of malaria [13], while quinolone derivatives have the potential for treatment or prevention of malaria through their unique antiparasitic effect against erythrocytic and hepatic stages of Plasmodium [14].
Which drug is derivative of quinoline?
Quinoline Derivatives
| Drug | Drug Description |
|---|---|
| Diiodohydroxyquinoline | Used in the treatment of amoebiasis. |
| Chlorquinaldol | Chlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment… |