What produces IL-21?
Sources of IL-21 and its major biological actions in different immune cell types. IL-21 is produced mainly by CD4 + T cells and NKT cells (see bold arrows), but it is also produced by CD8 + T cells.
What is the function of IL-21?
Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.
What is the function of IL-23?
IL-23 functions in innate and adaptive immunity, and is a key cytokine for promoting inflammatory responses in a variety of target organs. The most important function ascribed to IL-23 is its role in the development and differentiation of effector Th17 cells via activation of STAT3.
What is IL-2 used for?
Immunotherapy is cancer treatment that stimulates the body’s immune system to fight cancer, such as melanoma.
What type of signaling is the IL-2 signal?
cytokine signaling molecule
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system.
Is IL-10 a gene?
IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are ERK Signaling and Immune response IFN alpha/beta signaling pathway.
What is IL-21 (IL-21)?
IL-21 is produced predominantly by CD4+ T cells and natural killer T cells and, when aberrantly overexpressed, appears to play important roles in a wide variety of autoimmune disorders.
What is the role of IL-21 in T cell-B cell collaboration?
Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration During T cell-B cell collaboration, plasma cell (PC) differentiation and Ig production are known to require T cell-derived soluble factors.
Does IL-21 enhance IFN-gamma production in human T cells?
“IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells”. Journal of Immunology. 170 (11): 5464–9. doi: 10.4049/jimmunol.170.11.5464.
Is IL-21 an autocrine cytokine necessary for t (h) 17 differentiation?
IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T (H)17 differentiation, and serves as a target for treating inflammatory diseases. Research Support, N.I.H., Extramural