What is the primary purpose of prescribing both ritonavir and cobicistat?
Ritonavir is widely used to boost the effect of other PIs by blocking the CYP3A4 drug-metabolizing enzyme, which breaks down PIs. Cobicistat has a similar effect on CYP3A4 but has no direct impact on HIV.
Who manufactures ritonavir?
Antiretroviral Therapy for HIV-1 – NORVIR® (ritonavir) With more than 20 years of approved HIV-1 treatment, NORVIR is a well-known therapy. At AbbVie, we’re inspired daily by the people who don’t let a diagnosis stand in the way of their dreams.
What is boosted darunavir?
Boosted darunavir is an option for initial antiretroviral therapy, but now it is used more often as a common component of salvage regimens for treatment-experienced individuals.
What is darunavir used for?
Darunavir is used with a pharmacokinetic booster (a medication that increases the amount of other medications in the body) such as ritonavir (Norvir) or cobicistat (Tybost), and other medications to treat human immunodeficiency virus (HIV) infection in adults and children 3 years of age and older.
What is darunavir ritonavir?
Darunavir and Ritonavir are used in combination for treating patients suffering from HIV infection. It inhibits the replication of HIV.
What is the brand name for ritonavir?
Ritonavir (brand name: Norvir) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children older than 1 month. Ritonavir is always used in combination with other HIV medicines.
Why is ritonavir combined with darunavir?
The ‘boosting’ dose of ritonavir acts an an inhibitor of CYP3A, thereby increasing darunavir bioavailability. Drug interactions can result when darunavir is coadministered with other drugs that are inducers or inhibitors of, or act as substrates for, CYP3A.
Is darunavir a sulfa drug?
The primary disadvantages of darunavir include moderate gastrointestinal side effects, potential for drug interactions, and possible adverse reactions in individuals with history of severe sulfa allergy (darunavir contains a sulfonamide moiety).