What is miltefosine used for?
Miltefosine is used to treat certain types of leishmaniasis, such as visceral leishmaniasis (affects the internal organs), cutaneous leishmaniasis (affects the skin), or mucosal leishmaniasis (affects the nose, mouth, or throat). This medicine is available only with your doctor’s prescription.
What are Antimonial drugs?
Antimonials, in pre-modern medicine, were remedies principally containing antimony, used chiefly for emetic purposes. They might also have qualified for cathartic, diaphoretic, or simply alternative uses. Such treatments were considered unparalleled in their strength.
What class of drug is miltefosine?
Miltefosine belongs to the class of alkylphosphocholine drugs, which are phosphocholine esters of aliphatic long-chain alcohols.
How is sodium stibogluconate given?
Sodium stibogluconate is usually administered by intravenous or intramuscular injection daily at a dose of 20 mg/kg/day (maximum 850 mg) for 21–28 days. Intralesional injections may be used for a single lesion or a few small lesions of cutaneous leishmaniasis.
How much does miltefosine cost?
Miltefosine costs ~$57,600 for a 28-day regimen in the US, resulting in barriers to access due to high out of pocket costs (WHO, 2019). In contrast to albendazole, which has generic manufacturer competition, the sole manufacturer of miltefosine has orphan drug market exclusivity through March 2021.
What is rifabutin used for?
Rifabutin is used to help prevent Mycobacterium avium complex (MAC) disease from causing disease throughout the body in patients with advanced human immunodeficiency virus (HIV) infection. MAC is an infection caused by two similar bacteria, Mycobacterium avium and Mycobacterium intracellulare.
How do you say miltefosine?
Pronunciation
- (Received Pronunciation) IPA: /mɪlˈtɛf.ə.ziːn/
- (General American) IPA: /mɪlˈtɛf.əˌsin/
Is miltefosine safe for pregnancy?
Miltefosine and Pregnancy Do not take miltefosine if you are pregnant. If you take miltefosine during pregnancy, your baby is at risk for death or serious birth defects.
Is miltefosine available in India?
That individuals can buy as much of the drug as they can afford reflects the Indian system of drug dispensing — miltefosine is now widely available over the counter without prescription or restriction on the quantity dispensed.
What is post kala azar?
Post-kala-azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis (VL); it is characterised by a macular, maculopapular, and nodular rash in a patient who has recovered from VL and who is otherwise well.
What is pentavalent antimonial therapy?
The pentavalent antimonials, sodium stibogluconate or meglumine antimoniate, are drugs commonly used to treat cutaneous and mucocutaneous leishmaniasis.
What is antimonial lead?
Definition of antimonial lead : lead containing antimony specifically : a hard alloy of lead containing 4 to 10 percent antimony used for the framework of storage-battery plates and tank linings — compare grid metal, hard lead.
How many ampoules is 300 mg of glucantime?
Glucantime 5 ampoules 5 ml Reference: Condition: New product Metilglucamina antimoniato 300 mg. Excipientes, con sulfito sódico (0,18 mg) y metabisulfito potásico (1,60 mg), c.s. More details This product is no longer in stock Availability date: 20,50 €tax incl. Quantity The minimum purchase order quantity for the product is 1 Add to cart Print
What are the key facts of Paraguay?
The country’s Coat of Arms is on the front and its Treasury Seal is on the back with its motto, ‘Paz y Justica’ (Peace and Justice). Paraguay’s flag is one of the world’s oldest national flags. Flag of Paraguay. Image credit – CIA 14. Though Paraguay is a land-locked country with no border on the ocean, it has a well-trained navy.
What is Paraguay’s national motto?
Paraguay is the only country worldwide whose national flag has different emblems on each side. The country’s Coat of Arms is on the front and its Treasury Seal is on the back with its motto, ‘Paz y Justica’ (Peace and Justice).
Why is Guarani important in Paraguay?
Guarani is still spoken by everyone in Paraguay, regardless of their income, politics or social class. This is one of the country’s unifying strengths. Other indigenous heritages are its traditional 38-string harp music and the traditional bottle dance, performed with dancers twirling bottles around their heads.