What is chlormadinon 2mg fem used for?
Description: Chlormadinone is a progestogen structurally related to progesterone, with some anti-androgenic activity. It is used alone or combined with an estrogen in the treatment of menstrual disorders. It has also been used in some countries in the management of prostate cancer.
What class of drug is chlormadinone acetate?
Chlormadinone acetate
| Clinical data | |
|---|---|
| Routes of administration | By mouth |
| Drug class | Progestogen; Progestin; Progestogen ester; Antigonadotropin; Steroidal antiandrogen |
| ATC code | G03DB06 (WHO) |
| Legal status |
Does Belara help with acne?
After the intake of Belara for 12 cycles, acne on the face/neck improved in 64.1% of the women (209 of 326). In 53.4% of the women (175 of 326), acne disappeared completely. Seborrhea improved after 12 cycles in 89 of 131 women (67.9%), of whom 76 women (58.0%) were completely cured.
Is Belara a contraceptive?
Belara® is a modern oral hormonal contraceptive consisting of a monophasic combination of 2mg chlormadinone acetate and 0.03mg ethinylestradiol.
What is the difference between chlormadinone and CMA?
CMA is the C17α acetate ester of chlormadinone, which, in contrast to CMA, was never marketed. Analogues of CMA include other 17α-hydroxyprogesterone derivatives such as CPA, delmadinone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, and osaterone acetate.
Is chlormadinone acetate an antigonadotropic?
Chlormadinone acetate. It is also an antiandrogen, and hence is an antagonist of the androgen receptor, the biological target of androgens like testosterone and dihydrotestosterone. Due to its progestogenic activity, CMA has antigonadotropic effects. The medication has weak glucocorticoid activity and no other important hormonal activity.
What receptors does chlormadinone acetate bind to?
Chlormadinone acetate (CMA) is a potent progesterone receptor (PR) agonist, a partial androgen receptor (AR) antagonist and a weak glucocorticoid receptor (GR) antagonist. Chlormadinone binds to PRs, which induces the expression of progesterone -responsive genes.
What is the PMID for the progesterone derivative chlormadinone acetate?
PMID 16356876. S2CID 22898956. Druckmann R (April 2009). “Profile of the progesterone derivative chlormadinone acetate – pharmocodynamic properties and therapeutic applications”. Contraception. 79 (4): 272–81. doi: 10.1016/j.contraception.2008.10.017. PMID 19272496. Guerra-Tapia A, Sancho Pérez B (September 2011).