What does PGC 1 alpha do?
PGC-1alpha stimulates mitochondrial biogenesis and promotes the remodeling of muscle tissue to a fiber-type composition that is metabolically more oxidative and less glycolytic in nature, and it participates in the regulation of both carbohydrate and lipid metabolism.
What is PGC 1 alpha gene?
PGC-1α is a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors.
How can I activate AMPK and PGC-1α?
AMPK can be specifically activated by using the drug 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR). Treating muscle cells with AICAR leads to an increase in PGC-1α transcription (21, 23).
What is the function of PGC?
PGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors (NRF-1, 2) and mitochondrial transcription factor A (Tfam), which leads to increased mitochondrial DNA replication and gene transcription.
What is the Pparg gene?
6 days ago
PPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene. Diseases associated with PPARG include Lipodystrophy, Familial Partial, Type 3 and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Metabolism and Noncanonical Wnt signaling pathway.
Is PGC 1a a transcription factor?
At the PGC-1α promoter, there are binding sites for transcription factors myocyte enhancer factor 2 (MEF2), forkhead box class-O (FoxO1), activating transcription factor 2 (ATF2), and cAMP response element–binding protein (CREB), all of which enhance PGC-1α transcription.
What is PGC diabetes?
Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1α is involved in the regulation of T2DM.
Is Pparg a protein?
PPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene.
What is the role of SIRT1 and AMPK?
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure Metabolic sensors such as AMPK and SIRT1, gatekeepers of the activity of the master regulator of mitochondria, PGC-1alpha, are vital links in a regulatory network for metabolic homeostasis.
Does AMPK activation increase pgc-1α-mediated gene expression?
In a subsequent study, Canto and Auwerx (7) demonstrated that AMPK activation by AICAR increased PGC-1α-mediated gene expression in a SIRT1-dependent manner in C2C12myocytes and mouse embryonic fibroblasts.
What increases SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expression in skeletal muscle?
93. Suwa M, Nakano H, Radak Z, Kumagai S. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle. Metabolism57: 986–998, 2008.
Does SIRT1 promote ABCG2 production in colon cancer cells?
In a human colon carcinoma cell line, SIRT1 promoted ABCG2 production through the deacetylation of peroxisome proliferator-activated receptor (PPAR) γ co-activator 1α (PGC-1α), which then activated the effectors of PPARγ.