Is spindle cell lipoma cancerous?
A spindle cell lipoma is a non-cancerous tumour made up of fat and spindle cells. Spindle cell lipomas commonly grow around the upper back and neck but can start almost anywhere in the body. Most grow just under our skin where they feel like a soft lump.
What is a spindle cell lipoma?
Summary: Spindle cell lipomas (SCL) are benign, slow growing tumors arising most frequently in the subcutaneous tissue of the upper back, posterior neck, and shoulders in males aged 40–70 years. Local excision is generally curative.
Is spindle cell malignant or benign?
Some tumours are made up almost entirely of spindle cells. These tumours can be either benign (non-cancerous) or malignant (cancerous). The type of tumour depends on the location in the body and the way the cells look when examined under the microscope. Most cancers made up of spindle cells are called sarcomas.
What are spindle cells and their function?
Spindle cells, named after their long, spindle-shaped bodies, are the cells that are credited with allowing us to feel love and to suffer emotionally. Their discovery in whales will stimulate debate both on the level of whale intelligence and on the ethics of hunting them.
What does spindle cell neoplasm mean?
Spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. Spindle cell neoplasms can affect the oral cavity. In the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components.
What is benign spindle cell proliferation?
Fibrous Histiocytoma (Dermatofibroma) Fibrous histiocytoma is a common benign dermal mesenchymal tumor characterized histologically by the proliferation of mononuclear, spindle to round or histiocytic cells. Fibrous histiocytoma may develop at any age, but it usually presents during the third and fourth decades.
What are spindle cell lesions?
A type of tumor that contains cells called spindle cells, based on their shape. Under a microscope, spindle cells look long and slender. Spindle cell tumors may be sarcomas or carcinomas.
What is a low-grade spindle cell neoplasm?
Low-grade fibromyxoid sarcoma (LGFMS) is a rare sarcoma characterized by bland histologic features and a paradoxically aggressive clinical course. The hyalinizing spindle cell tumor with giant rosettes (HSCT) is a closely related tumor characterized by the presence of giant collagen rosettes.
What causes spindle cell lipoma?
Spindle cell lipoma, a distinct histological variant of lipoma, originates from adipose tissue, and is characterized by the replacement of mature fat by collagen-forming spindle cells. The lesion was originally described by Enzinger and Harvey [2] in 1975, and accounts for about 1.5% of all lipomas [1].
What is the best treatment for lipoma?
The most common way to treat a lipoma is to remove it through surgery . This is especially helpful if you have a large skin tumor that’s still growing. Your doctor will typically carry out an excision procedure with you under a local anesthetic. They will make an incision in your skin to remove the lipoma.
Is spindle cell carcinoma serious?
Spindle cell carcinoma (SpCC) is a very rare tumor with a poor prognosis. The literature on the treatment and disease progression is still very limited, and there is a need for publishing long-term follow-up of such patients.
What does CD34 positive spindle cell lipoma mean?
Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm that may provide diagnostic difficulty to the histopathologist.
What is spindle cell lipoma (SCL)?
Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm that may provide diagnostic difficulty to the histopathologist. Four retrospectively identified SCLs were evaluated immunohistochemically with a broad panel of antibodies (CD34, factor XIIIa, S-100, actin and factor VIII).
Which immunohistochemistry findings are characteristic of spindle cell lipoma (SC)?
Immunohistochemistry is sometimes useful in the diagnosis of spindle cell lipoma, especially in relatively “fat-free” examples, as constituent spindle cells are positive for CD34 and vimentin but negative for S-100 protein, actins, and desmin. Spindle cell lipoma may simulate a dermatofibrosarcoma protuberans in a small biopsy sample.
What are the CD34 positive tumors of skin cancer?
Dermatofibrosarcoma protuberans, neurofibroma, schwannoma and angiolipoma are CD34 positive tumors that have some similar histologic features to SCL and may be considered in the differential diagnosis. Differentiation is possible using a broad panel of immunostains and routine diagnostic criteria. MeSH terms