Is IL-12 anti-inflammatory?

IL-12 can aid in the activation and regulation of several cytotoxic immune cells including macrophages, natural killer cells, and T cells, thus making it a ‘pro-inflammatory cytokine’.

How is IL-12 produced?

Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol.

Is IL-12 a proinflammatory cytokine?

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

Do T cells express IL-12?

The IL-12R complex is found on NK cells, NK T and activated T cells14 but has also been detected on cell types of myeloid origin15 and tonsillar B cells. Naive T cells express IL-12Rβ1 but not IL-12Rβ2, which is critical for the signal transduction downstream of the receptor complex.

Is Il 12p70 proinflammatory?

IL-12p70 is a heterodimer composed of p35 and p40 and is a pro-inflammatory cytokine that enhances Th1 (40, 41), cytotoxic CD8+ T (42), and NK (43) cell responses by increasing IFN-γ production (44).

What is an IL-12 inhibitor?

Interleukin-12 (IL-12) and IL-23 promote cellular responses mediated by T cells, which contribute to an inflammatory loop responsible for the induction and maintenance of psoriatic plaques. Antibodies that inhibit IL-12/23 or IL-23 are key treatment options for patients with psoriasis.

Which cytokines are anti inflammatory?

Major anti-inflammatory cytokines include interleukin (IL)-1 receptor antagonist, IL-4, IL-6, IL-10, IL-11, and IL-13. Specific cytokine receptors for IL-1, tumor necrosis factor-alpha, and IL-18 also function as proinflammatory cytokine inhibitors.

What is IL-12 and how does it work?

IL-12 induces cytokine production, primarily of IFN-γ, from NK and T cells, acts as a growth factor for activated NK and T cells, enhances the cytotoxic activity of NK cells, and favors cytotoxic T lymphocyte generation. In vivo IL-12 acts primarily at three stages during the innate resistance/adaptive immune response to infection: 1.

What is the role of IL-12 in Th1 cell differentiation?

IL-12 and IL-12-induced IFN-gamma favor Th1 cell differentiation by priming CD4+ T cells for high IFN-gamma production; and 3. IL-12 contributes to optimal IFN-gamma production and to proliferation of differentiated Th1 cells in response to antigen.

What is included in the quarterly performance review example?

This quarterly performance review example has sections for both achievements and areas of improvement. It also has a section for core values, as this must be a key performance indicator at this company. Different companies will have different measuring sticks for success. Q: Can I customize the performance review templates in this post?

Is your annual performance review taking time away from your work?

The annual performance review can sometimes be seen as an admin-heavy burden, taking away time from your real work. However, taking the time to complete your self evaluation is an important opportunity for employees.