Is IL-12 anti-inflammatory?

Is IL-12 anti-inflammatory?

IL-12 can aid in the activation and regulation of several cytotoxic immune cells including macrophages, natural killer cells, and T cells, thus making it a ‘pro-inflammatory cytokine’.

How is IL-12 produced?

Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol.

Is IL-12 a proinflammatory cytokine?

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

Do T cells express IL-12?

The IL-12R complex is found on NK cells, NK T and activated T cells14 but has also been detected on cell types of myeloid origin15 and tonsillar B cells. Naive T cells express IL-12Rβ1 but not IL-12Rβ2, which is critical for the signal transduction downstream of the receptor complex.

Is Il 12p70 proinflammatory?

IL-12p70 is a heterodimer composed of p35 and p40 and is a pro-inflammatory cytokine that enhances Th1 (40, 41), cytotoxic CD8+ T (42), and NK (43) cell responses by increasing IFN-γ production (44).

What is an IL-12 inhibitor?

Interleukin-12 (IL-12) and IL-23 promote cellular responses mediated by T cells, which contribute to an inflammatory loop responsible for the induction and maintenance of psoriatic plaques. Antibodies that inhibit IL-12/23 or IL-23 are key treatment options for patients with psoriasis.

Which cytokines are anti inflammatory?

Major anti-inflammatory cytokines include interleukin (IL)-1 receptor antagonist, IL-4, IL-6, IL-10, IL-11, and IL-13. Specific cytokine receptors for IL-1, tumor necrosis factor-alpha, and IL-18 also function as proinflammatory cytokine inhibitors.

What is IL-12 and how does it work?

IL-12 induces cytokine production, primarily of IFN-γ, from NK and T cells, acts as a growth factor for activated NK and T cells, enhances the cytotoxic activity of NK cells, and favors cytotoxic T lymphocyte generation. In vivo IL-12 acts primarily at three stages during the innate resistance/adaptive immune response to infection: 1.

What is the role of IL-12 in Th1 cell differentiation?

IL-12 and IL-12-induced IFN-gamma favor Th1 cell differentiation by priming CD4+ T cells for high IFN-gamma production; and 3. IL-12 contributes to optimal IFN-gamma production and to proliferation of differentiated Th1 cells in response to antigen.

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