Is chronic refractory gout a rare disease?

Is chronic refractory gout a rare disease?

Refractory gout is a rare form of gout. This condition can be painful and serious. People with refractory gout can also have problems with the kidneys.

What is chronic refractory gout?

Refractory gout (also known as treatment failure gout) is a clinical condition that is characterized by serum uric acid levels that do not fall below 6 mg/dL, and ongoing symptoms of recurrent flares, chronic inflammatory arthritis, and increased tophi.1.

How many people have chronic gout?

The condition now affects about 8.3 million people, or 4% of the population. And the risk of getting gout increases with age.

How often is chronic gout?

Chronic gout is having 2 or more gout attacks per year. Often more than one joint is affected.

Can chronic gout be reversed?

Gout is one of the most common inflammatory arthritides. The disease is due to the deposition of monosodium urate crystals. These deposits are reversible with proper treatment, suggesting that gout is a curable disease.

What is the difference between gout and chronic gout?

It occurs when uric acid builds up in blood and causes inflammation in the joints. Acute gout is a painful condition that often affects only one joint. Chronic gout is the repeated episodes of pain and inflammation. More than one joint may be affected.

What is the incidence of gout?

Recent reports of the prevalence and incidence of gout vary widely according to the population studied and methods employed but range from a prevalence of <1% to 6.8% and an incidence of 0.58–2.89 per 1,000 person-years. Gout is more prevalent in men than in women, with increasing age, and in some ethnic groups.

What is the prevalence of gout in Australia?

Self-reported data from the Australian Bureau of Statistics 2017–18 National Health Survey shows that an estimated 4.5% of Australians have gout. Gout is more common in males than females—almost 8 in 10 (79%) people with gout are males (ABS 2019).

Is gout caused by kidney failure?

Kidney disease can lead to gout When you have kidney disease, your kidneys cannot filter out uric acid as well as they should. Too much uric acid building up in the body is the cause of gout. Most people with early stage kidney disease do not know they have it.

Is gout a hard lump?

People with chronic gout may feel tiny, hard lumps building up over time in the soft flesh of areas like the hands, elbows, feet, or earlobes. These deposits are called tophi. They’re concentrations of uric acid crystals and can cause pain and stiffness over time.

Is gout more common in males or females?

Gout is more common in men than women, with only 5.1% of the US gout population being female [2, 3].

Which country has the most gout cases?

But the highest prevalence worldwide is reported in Taiwanese aboriginals and Maori, with some estimates of more than 10%. Gout is reportedly rare in former Soviet Union regions, Guatemala, Iran, Malaysia, Philippines, Saudi Arabia, rural Turkey and African countries, the authors note.

What is the pathogenesis of refractory gout?

Pathogenesis. Refractory gout is considered an uncommon problem, but it remains a persistent challenge, and patients with this condition can have functional impairment and sharply reduced quality of life. 1 Gout may result from chronic hyperuricemia, defined as a serum urate level >7.0 mg/dL in men and >6.0 mg/dL in women.

What is the global prevalence of gout?

• Gout is the most common form of inflammatory arthritis • Est. prevalence in U.S. 2007-2008: 3.9% (8.3 million) • Prevalence is increasing worldwide • Incidence is greater in men than in women • Incidence increases with age –Mainly due to proportional decline in renal function • Refractory gout estimated to be 2% of all gout patients

Is refractory gout intractable?

Despite the availability of therapies, there remains a subset of patients with gout who, despite aggressive therapy, have intractable disease (i.e., patients with refractory gout). 1, 10 ,11

What are the treatment options for refractory gout?

Treatment options for Refractory Gout • Dose escalation of conventional urate lowering therapies: •allopurinol to 800 mg daily in divided doses •febuxostat to 160 –240 mg daily •probenecid to 1000 mg daily in divided doses •lesinurad to 200 mg daily