How is interleukin-2 administered?
Interleukin-2 is given in two different ways. It can be given in higher doses into a vein (IV, intravenously) while the patient is monitored in the hospital. It can also be given in a low-dose regimen via a shot placed under the skin (SubQ, subcutaneous injection).
Who manufactures Proleukin?
Clinigen Group plc
Clinigen Group plc (AIM: CLIN, ‘Clinigen’ or the ‘Group’), the global pharmaceutical and services company, has completed the acquisition of the US rights to Proleukin® (aldesleukin, human recombinant interleukin-2), following US anti-trust clearance.
How is aldesleukin administered?
Aldesleukin comes as a powder to be mixed with liquid to be injected over intravenously (into a vein) over 15 minutes by a doctor or nurse in a hospital. It is usually injected every 8 hours for 5 days in a row (a total of 14 injections). This cycle may be repeated after 9 days.
Is IL-2 a drug?
Aldesleukin is an immunotherpay drug. It is also known as interleukin 2 (IL-2) or by its brand name Proleukin. It is a treatment for kidney cancer that has spread to another part of the body (advanced kidney cancer). It is also used in clinical trials for other types of cancer.
Is Proleukin a biologic?
Proleukin is classified as a “biologic response modifier (BRM)” or “biologic therapy.” BRMs modify the body’s response to cancer cells.
How does interleukins treatment work?
Interleukin-2 works by: Blocking the reproduction and spread of cancer cells. Stimulating the development of white blood cells that attack cancer. Causing cancer cells to release chemicals that attract cancer-killing immune system cells.
What is Proleukin used for?
Aldesleukin is used to treat kidney or skin cancer. This medication is the same as a substance that your body normally makes (interleukin-2). In the body, this drug is thought to work by affecting the body’s natural defenses (immune system).
How do interleukin treatment work?
What type of drug is Proleukin?
Proleukin is classified as a “biologic response modifier (BRM)” or “biologic therapy.” BRMs modify the body’s response to cancer cells. Interleukin-2 is part of a family of proteins called cytokines.
How many chemo sessions are needed for leukemia?
The treatment usually consists of four cycles of intensive chemotherapy that includes high doses of cytarabine and one or more other drugs.
What is an interleukin 6 test?
What is being tested? Interleukin-6 (IL-6) is a protein produced by various cells. It helps regulate immune responses, which makes the IL-6 test potentially useful as a marker of immune system activation. IL-6 can be elevated with inflammation, infection, autoimmune disorders, cardiovascular diseases, and some cancers.
How many milligrams of Proleukin are in an infusion?
Proleukin Dosage. Generic name: aldesleukin 1.1mg in 1mL. Dosage form: injection, powder, lyophilized, for solution. Medically reviewed by Drugs.com. Last updated on Sep 10, 2019. The recommended Proleukin® (aldesleukin) treatment regimen is administered by a 15-minute intravenous infusion every 8 hours.
How much Proleukin should be diluted for delivery?
In cases where the total dose of Proleukin is 1.5 mg or less (e.g., a patient with a body weight of less than 40 kilograms), the dose of Proleukin should be diluted in a smaller volume of D5W. Concentrations of Proleukin below 0.03 mg/mL and above 0.07 mg/mL have shown increased variability in drug delivery.
When should a dose of Proleukin be held and restarted?
Doses should be held and restarted according to the following: Concentrations of Proleukin below 0.03 mg/mL and above 0.07 mg/mL have shown increased variability in drug delivery. Dilution and delivery of Proleukin outside of this concentration range should be avoided.
What is the generic name for Proleukin?
Proleukin Dosage. Generic name: aldesleukin 1.1mg in 1mL. Dosage form: injection, powder, lyophilized, for solution. Medically reviewed on August 31, 2018. The recommended Proleukin® (aldesleukin) treatment regimen is administered by a 15-minute intravenous infusion every 8 hours.