How do you make dexrazoxane?
Preparation: Dexrazoxane must be reconstituted with 0.167 Molar (M/6) Sodium Lactate Injection USP to give a concentration of 10 mg dexrazoxane for each mL of sodium lactate. The reconstituted solution should be given by slow I.V. push or rapid drip intravenous infusion from a bag.
What is the antidote for cyclophosphamide?
No specific antidote for cyclophosphamide is known. Overdosage should be managed with supportive measures, including appropriate treatment for any concurrent infection, myelosuppression, or cardiac toxicity should it occur.
How many hours after an epirubicin extravasation is the antidote initiated?
Extravasation Management. Apply ice for 6-12 hours following sodium thiosulfate antidote injection (Merck and Co., Inc., 2005).
Which drug is the antidote of methotrexate?
Glucarpidase. Glucarpidase is an antidote (remedy) for methotrexate toxicity. It’s usually given in combination with leucovorin to help prevent severe and potentially life-threatening methotrexate toxicity.
What is dexrazoxane used for?
Dexrazoxane injection (Totect, Zinecard) is used to prevent or decrease thickening of the heart muscles caused by doxorubicin in women who are taking the medication to treat breast cancer that has spread to other parts of the body.
When do you give Zinecard?
ZINECARD is indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m and who will continue to receive doxorubicin therapy to maintain tumor control.
What is the Hcpcs code for dexrazoxane Hydrochloride injection 250mg?
J1190
HCPCS Code for Injection, dexrazoxane hydrochloride, per 250 mg J1190.
How is Cytoxan given?
It is usually given through a vein by injection or infusion (intravenous, IV) or by mouth in tablet form, depending upon diagnosis. Cyclophosphamide is also approved to be given by a shot into a muscle (IM), into the abdominal lining (intraperitoneal, IP), or into the lining of the lung (intrapleural).
What is the chemical name of dexrazoxane?
Zinecard (dexrazoxane for injection), a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate intended for intravenous administration. Chemically, dexrazoxane is (S)-4,4′- (1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione. The structural formula is as follows:
What is the chemical formula for zinecard?
DESCRIPTION ZINECARD®(dexrazoxane for injection) is a sterile, pyrogen-free lyophilizate intended for intravenous administration. It is a cardioprotective agent for use in conjunction with doxorubicin. Chemically, dexrazoxane is (S)-4,4′-(1-methyl-1,2-ethanediyl)bis-2,6piperazinedione. The structural formula is as follows:
Is doxorubicin and zinecard the same thing?
Zinecard (dexrazoxane for injection), a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate intended for intravenous administration. Chemically, dexrazoxane is (S)-4,4′-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione.
Is there an antidote for dexrazoxane?
There is no known antidote for dexrazoxane. Instances of suspected overdose should be managed with good supportive care until resolution of myelosuppression and related conditions is complete. Management of overdose should include treatment of infections, fluid regulation, and maintenance of nutritional requirements. 11 DESCRIPTION