How common is mannose binding lectin deficiency?

Mannose-binding lectin (MBL) deficiency is a condition that affects the immune system. It is a fairly common condition, affecting approximately 5–30 people in every 100. People with this condition have low levels of an immune system protein called mannose-binding lectin in their blood.

Is mannose binding lectin deficiency rare?

Mannose-binding lectin deficiency is thought to affect approximately 5 to 10 percent of people worldwide; however, many affected individuals have no signs or symptoms related to low mannose-binding lectin levels.

Is MBL deficiency and autoimmune disease?

Interestingly, absence or extremely low concentration of serum MBL (MBL deficiency) seems to be a risk factor for occurrence of autoimmune diseases, in particular systemic lupus erythematosus. In addition, individuals with MBL deficiency are at risk of infection when in immunocompromised conditions.

Where is mannose-binding lectin found?

Mannose-binding lectin recognizes and attaches (binds) to sugars, such as mannose, fucose, and glucose, that are found on the surface of bacteria, viruses, and yeast.

Is mannose-binding lectin deficiency an autoimmune disease?

Where does mannose-binding lectin come from?

It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins.

Is mannose-binding lectin a complement?

Mannan-binding lectin, also called mannose-binding protein, is a protein belonging to the collectin family that is produced by the liver and can initiate the complement cascade by binding to pathogen surfaces.

Which statement is not accurate regarding mannose-binding lectin MBL?

Which statement is NOT accurate regarding mannose-binding lectin (MBL)? It binds proteins on bacterial surfaces. Deficiencies in early parts of the classical pathway (C1q, C1r, C1s, C2, C4) share all of these traits EXCEPT: similar phenotypes because all these components are essential.

Is MBL deficiency genetic?

The quality of life for those affected is good if infections are mild and/or treated promptly. Genetic changes (known as mutations) in the MBL2 gene can lead to MBL deficiency.