What is Nuclear B catenin?

Abstract. Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes.

Is beta catenin downstream of Wnt?

β-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland.

Is beta catenin stabilized by Wnt?

Wnts also stabilize β-catenin via inhibition of GSK-3β, but, in contrast to hypertrophic signaling, this is not believed to involve PKB-induced Ser-9 phosphorylation (16, 32).

What is the role of B catenin?

Beta-catenin is the central component of the Wnt signaling pathway, with a key role in the regulation of cell proliferation, differentiation, and apoptosis. In the liver, β-catenin promotes hepatic regeneration. In humans, β-catenin is mutated in up to 44% of HCC.

What genes does B catenin activate?

In the nucleus β-catenin activates transcription of Wnt/β-catenin-target genes such as c-myc and cyclinD1 (Maretzky et al, 2005; Reiss et al, 2005).

Does ββ-catenin/TCF4 complex induce epithelial-to-mesenchymal transition?

β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness Proc Natl Acad Sci U S A.

How does TRIB3 interact with beta catenin and TCF4?

TRIB3 interacts with β-catenin and TCF4 in intestine cells to increase expression of genes associated with cancer stem cells. Knockdown of TRIB3 decreases colon neoplasia in mice, migration of CRC cells, and their growth as xenograft tumors in mice. Strategies to block TRIB3 activity might be develo …

How do β-catenin and TCF4 activate ZEB1?

We found that β-catenin/TCF4 binds directly to the ZEB1 promoter and activates its transcription. Knockdown of β-catenin and TCF4 in APC-mutated CRC cells inhibited endogenous ZEB1, whereas forced translocation of β-catenin to the nucleus in APC-wild-type CRC cells induced de novo expression of ZEB1.

How does beta-catenin activate T-cell factor-dependent transcription?

Upon translocation to the nucleus beta-catenin serves as an activator of T-cell factor (Tcf)-dependent transcription leading to an increased expression of several specific target genes including c-Myc, cyclin D1, MMP-7, and ITF-2.