What is the use of pantoprazole for injection?
Pantoprazole injection is used to treat certain conditions in which there is too much acid in the stomach. It is used for short-term treatment (7 to 10 days) of gastroesophageal reflux disease (GERD) with a history of erosive esophagitis.
How do you prepare pantoprazole injection?
PROTONIX I.V. for Injection admixtures should be administered intravenously over a period of approximately 15 minutes at a rate of approximately 7 mL/min. PROTONIX I.V. for Injection should be reconstituted with 10 mL of 0.9% Sodium Chloride Injection, USP, to a final concentration of approximately 4 mg/mL.
Is pantoprazole a injection?
How to use Pantoprazole SODIUM Vial. This medication is given by injection into a vein as directed by your doctor. The dosage and length of treatment are based on your medical condition and response to treatment.
Can pantoprazole injection be given IM?
Pantoprazole injection is for intravenous use only; do not administer intramuscularly or by subcutaneous injection. Administer pantoprazole IV either through a dedicated IV line or a Y-site.
Is pantoprazole injection safe?
Long-term use of this medicine may lead to an increased risk of side effects. For instance, using this medicine for more than 1 year may increase your risk for bone fractures, especially with higher doses. Talk to your doctor about ways to prevent bone loss (osteoporosis), like taking calcium and vitamin D supplements.
Can pantoprazole be given subcutaneously?
Conclusions: Pantoprazole given subcutaneously promoted a reduction in gastric acid secretion and was associated with improved healing of the sutured gastric incision in the fundus (squamous epithelium) of rats.
What is the difference between IM and IV?
IV, or intravenous, injections are administered into the bloodstream either by a syringe or by a low pressure method known as a drip. The intramuscular shots are administered into the muscle, not the vein. Your muscles have a greater number of blood vessels that are also larger than the subcutaneous tissue.
Can pantoprazole be given subcutaneously in dogs?
Dosing Information of Pantoprazole (Protonix) for Dogs Pantoprazole is commonly dosed at 0.3 to 0.45 mg per pound (0.7 to 1 mg/kg) once daily. It can be given intravenously (IV) or orally. Do not give intramuscularly (IM) or subcutaneously (SQ).
Can omeprazole be given subcutaneously?
If the solutions are diluted and administered slowly, they are less likely to cause tissue irritation or other complications. Furthermore, subcutaneous omeprazole has been safely administered in animal studies and has shown a dose-dependent reduction in gastric H+K+ATPase activity.
How do you reconstitute pantoprazole?
For Injection: 40 mg pantoprazole white to off-white lyophilized powder in a single-dose vial for reconstitution. For Injection: 40 mg pantoprazole white to off-white lyophilized powder in a single-dose vial for reconstitution.
What is the dosage for pantoprazole sodium for injection?
The recommended adult dosage of Pantoprazole Sodium for Injection is 80 mg intravenously every 12 hours. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements. In those patients who need a higher dosage, 80 mg intravenously every 8 hours is expected to maintain acid output below 10 mEq/h.
How does pantoprazole affect gastric acid secretion?
Intravenous pantoprazole sodium maintained or improved control of gastric acid secretion. In both studies, total doses of 160 or 240 mg intravenous pantoprazole, administered in divided doses, maintained basal acid secretion below target levels in all patients.
How many milligrams of pantoprazole should a rat take?
In a 24-month carcinogenicity study, Fischer 344 rats were treated orally with pantoprazole doses of 5 to 50 mg/kg/day, approximately 1 to 10 times the recommended human dose based on body surface area.