What are polymorphisms used for?
Single nucleotide polymorphisms can be used as genetic markers for constructing high genetic maps and to carry out association studies related to diseases because of their abundance and the availability of high throughput analysis technologies.
What is SNP data?
A SNP is a variation of a single nucleotide between individuals. These polymorphisms can therefore be used to discern small differences both within a population and among different populations. The beauty of SNPs is that the observed variation can be followed over time and quantified.
How does NCBI use SNP database?
Go to NCBI web page http://www.ncbi.nlm.nih.gov/. Select the “SNP” database from the “All Databases” pull down menu at the top of the page (Figure 1.19. 1). Alternatively, click on “Variation” link in the green box on the left of the web page.
How do I check my NCBI SNP?
Go to the 1000 Genomes Browser. Go to the search section in the left section and enter a gene symbol in the query box. Select the populations for which you want to review allele frequences or genotype counts per SNP.
What is a polymorphic site?
Polymorphism involves one of two or more variants of a particular DNA sequence. The most common type of polymorphism involves variation at a single base pair. Polymorphisms can also be much larger in size and involve long stretches of DNA.
How does polymorphism work?
Polymorphism is the ability of an object to take on many forms. The most common use of polymorphism in OOP occurs when a parent class reference is used to refer to a child class object. Any Java object that can pass more than one IS-A test is considered to be polymorphic.
Is SNP a point mutation?
SNPs are nonfunctional point mutations that occur at a frequency of about 1% in the human genome. Because many SNPs have been sequenced, they can be used to compare the haplotypes of cancer genomes with other nontumor DNA from the same individual.
How are SNPs detected?
Single nucleotide polymorphisms (SNPs) can be detected via allele-specific PCR, using either primers or probes. Several techniques are available for detecting SNPs, including hyperchromicity, intercalating dyes, colorimetric or fluorescent dye detection and fluorescence polarization melting curve analysis.
What is polymorphism in database design?
Here is a sample data set: Polymorphism is an object oriented design concept not a database one. Typically, to bridge the gap between a database and application, and make the former appear object oriented, a tool such as Hibernate is used.
What is the database of rheumatoid arthritis-related polymorphisms?
In this study, we developed the Database of Rheumatoid Arthritis-related Polymorphisms (RADB), to integrate all the RA-related genetic polymorphisms and provide a useful resource for researchers.
How many von Willebrand factor (vWF) polymorphisms are there?
Nucleotide sequence polymorphisms in the von Willebrand factor (vWF) gene are useful for genetic studies in von Willebrand disease (vWD). This database describes 33 known vWF polymorphisms distributed throughout the vWF gene. DNA sequence information is available for 21 of these sites. The most info …
Why can’t I assign polymorphisms to the vWF gene and pseudogene?
Because the vWF gene and pseudogene have diverged only approximately 3.1% in DNA sequence, correct assignment of polymorphisms to either locus can be difficult in the region of homology. This problem has been solved in some cases by comparison of the published sequences and predicted restriction maps for the gene and pseudogene.