How is vitamin D metabolized?
The metabolism of vitamin D. The liver converts vitamin D to 25OHD. The kidney converts 25OHD to 1,25(OH)2D and 24,25(OH)2D. Other tissues contain these enzymes, but the liver is the main source for 25-hydroxylation, and the kidney is the main source for 1α-hydroxylation.
What is the biochemistry of vitamin D?
Vitamin D is a derivative of 7-dehydrocholesterol, also called ergosterol. This conversion is mediated by the action of ultraviolet radiation the parent compound, which is formed in the Malpighian layer of skin during a relatively minor route of cholesterol synthesis.
How fast is vitamin D metabolized?
Vitamin D Metabolism The half-life of calcidiol is 15 days. This means that after 15 days, half of the vitamin D from an oral supplement has left the body and that 30 days after a dose of vitamin D only 25 percent of the vitamin remains.
How many vitamin D metabolites are there?
The three main steps in vitamin D metabolism, 25-hydroxylation, 1α-hydroxylation, and 24-hydroxylation are all performed by cytochrome P450 mixed-function oxidases (CYPs).
What is the role of vitamin D in calcium metabolism?
Vitamin D functions by stimulating intestinal calcium and phosphorus absorption, by stimulating bone calcium mobilization, and by increasing renal reabsorption of calcium in the distal tubule. These functions on bone and possibly kidney, but not intestine, require the parathyroid hormone.
Which of the following tissues is important in vitamin D metabolism?
For physiological functioning, vitamin D3 must be metabolized first by the liver to 25-hydroxyvitamin D3 and then by the kidney to the final hormonal product, 1,25-dihydroxyvitamin D3 (calcitriol).
What are active vitamin D metabolites?
The biologically active metabolite of vitamin D, 1,25(OH)2D3, affects mineral homeostasis and has numerous other diverse physiological functions including effects on growth of cancer cells and protection against certain immune disorders.
Does vitamin D regulate energy metabolism?
High Dosage of Vitamin D Regulates the Energy Metabolism and Increases Insulin Sensitivity, but are Associated with High Levels of Kidney Damage. Drug Dev Res.
What vitamins can I take to boost my metabolism?
B vitamins. A variety of B vitamins are important for metabolism.
What is the metabolic role of vitamin D?
– Humans – Metabolic Syndrome / etiology* – Risk Factors – Vitamin D / metabolism – Vitamin D Deficiency / complications*
What is optimal daily dose of vitamin D?
The recommended daily amount of vitamin D is 400 international units (IU) for children up to age 12 months, 600 IU for people ages 1 to 70 years, and 800 IU for people over 70 years. Research on vitamin D use for specific conditions shows:
Which vitamin helps with your metabolism levels?