Can heparin and INTEGRILIN be given together?
INTEGRILIN should be given concomitantly with heparin to achieve a target ACT of 200 to 300 seconds. Administer 60-units/kg bolus initially in patients not treated with heparin within 6 hours prior to PCI. Additional boluses during PCI to maintain ACT within target.
How is the drug eptifibatide INTEGRILIN used?
Eptifibatide injection is used to prevent blood clots from forming in the arteries of the heart after certain types of chest pain and heart attacks. It may also be used in patients who are having certain heart and blood vessel procedures, such as coronary angioplasty.
Is INTEGRILIN a platelet inhibitor?
Eptifibatide reversibly inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive ligands to GP IIb/IIIa.
When do you use INTEGRILIN?
INTEGRILIN is indicated for the prevention of early myocardial infarction in adults presenting with unstable angina or non-Q-wave myocardial infarction, with the last episode of chest pain occurring within 24 hours and with electrocardiogram (ECG) changes and/or elevated cardiac enzymes.
Can you take Plavix with low platelets?
During follow-up, it was recommended that patients stop taking clopidogrel if he or she had bleeding or thrombocytopenia (<100 × 10 9/l).
Which antibiotics cause low platelets?
Medicines Known to Cause DITP
| Medicine Classification | Examples of Implicated Medicines |
|---|---|
| Antibiotics | Cephalosporins, linezolid, penicillins, sulphonamides, trimethoprim, vancomycin |
| Antimalarials | Quinine |
| Antimycobacterials | Ethambutol, rifampicin |
| Antiepileptics | Carbamazepine, phenytoin, sodium valproate |
Is INTEGRILIN a blood thinner?
BRAND NAME(S): Integrilin. USES: Eptifibatide is a type of “blood thinner” used to prevent blood clots that can cause a heart attack or other serious blood flow problems.
Can I take clopidogrel and atorvastatin at the same time?
The investigators concluded that patients who took atorvastatin and clopidogrel together had almost a 2-fold—increased risk of major adverse events at 30 days compared with patients on clopidogrel alone.
Can atorvastatin be taken with clopidogrel?
Talk to your doctor before using atorvastatin and clopidogrel. This combination may reduce the effects of clopidogrel. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity.
What medication increases platelets?
Drugs that boost platelet production. Medications such as romiplostim (Nplate) and eltrombopag (Promacta) help your bone marrow produce more platelets. These types of drugs can increase your risk of blood clots.
What causes thrombocytopenia after the administration of Integrilin?
These findings suggest acute thrombocytopenia after the administration of Integrilin can develop as a result of naturally occurring drug-dependent antibodies or those induced by prior exposure to Integrilin. Similar antibodies were identified with other GP IIb/IIIa ligand-mimetic agents.
What is Integrilin used to treat?
Integrilin is used to prevent blood clots or heart attack in people with severe chest pain or other conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries). Integrilin may also be used for purposes not listed in this medication guide.
How is drug-induced thrombocytopenia (dit) treated?
Thus, the primary treatment for drug-induced thrombocytopenia is to discontinue the suspected causative agent. Patients experiencing life-threatening bleeding may benefit from intravenous immunoglobulin (IVIG) therapy, plasmapheresis, or platelet transfusions [9;10]. Corticosteroids seem inefficient in the treatment of DIT [11]. III. ETIOLOGY
How is Integrilin administered to prevent platelets?
Integrilin 1 Integrilin (eptifibatide) helps to prevent platelets in your blood… 2 Important information. You should not receive Integrilin if you are also being treated… 3 Before receiving Integrilin. To make sure you can safely receive Integrilin,… 4 Integrilin is injected into a vein through an IV.