Can capecitabine be used alone?

Can capecitabine be used alone?

Capecitabine is a type of chemotherapy. It is used as a treatment for different types of cancer, including bowel cancer. You might have capecitabine on its own or with other chemotherapy drugs. You might also have it with radiotherapy.

How is Xeloda dosed?

The recommended dose of XELODA is 1250 mg/m2 administered orally twice daily (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1-week rest period given as 3-week cycles (see Table 1).

What is single agent chemotherapy?

Chemotherapy drugs can be given alone (single agent) or two or more drugs can be given together (combination chemotherapy). The aim of this review was to compare whether using a more intensive regimen (more than one drug) was better than the single agent treatment for women with advanced disease.

How do you take capecitabine 500mg?

Take this medication by mouth as directed by your doctor, usually 2 times a day; once in the morning and once in the evening. Swallow the tablets whole with a full glass of water (8 ounces/240 milliliters) within 30 minutes after a meal. Do not crush or split the tablets.

What is capecitabine 500 mg used for?

Capecitabine is used to help treat patients with Dukes’ C colon cancer (colon cancer that has spread to lymph nodes in the area close to the colon), after having surgery. This medicine is also used to treat metastatic colorectal cancer (cancer of the colon or rectum that has spread to other parts of the body).

Can capecitabine be cut in half?

Do not cut, crush, break, or chew it. If the tablet must be cut or crushed, it should be done by a pharmacist.

How do you give capecitabine?

How Capecitabine Is Given:

  1. Taken as a pill by mouth.
  2. Take after food (within 30 minutes of a meal) with water. (Usually taken in a divided dose 12 hours apart).
  3. Tablets come in 2 sizes; 150mg and 500mg.
  4. Do not crush, chew or dissolve tablets.
  5. If you miss a dose, skip the missed dose and go back to your normal time.

Does capecitabine have to be taken 12 hours apart?

Capecitabine works best if it is broken down in the stomach when the stomach is full. Take it in the morning after breakfast and then again after dinner. The doses should be spaced 10 to 12 hours apart. Tell your doctor if you have difficulty swallowing the pills.

Can you crush capecitabine tablets?

How many cycles of capecitabine can you take?

You have oxaliplatin and capecitabine chemotherapy as cycles of treatment. This means you have the drugs and then a rest to allow your body to recover. Each cycle lasts 3 weeks (21 days). Depending on your needs, you may have between 4 and 8 cycles.

What is the most effective single agent chemotherapy drug?

Phase II trials have demonstrated responses of 15% to 30% for these agents, with cisplatin, mitomycin, 5-fluorouracil, paclitaxel, and vindesine being the most active.

What is single agent system?

They are independent entities with their own goals, actions, and knowledge. In a single-agent system, no other such entities are recognized by the agent. Thus, even if there are indeed other agents in the world, they are not modeled as having goals, etc.: they are just considered part of the environment.

What is the maximum daily dose of capecitabine?

None of the patients on single-agent capecitabine (19) developed toxicity of any grade. The total daily dose of capecitabine was 830 to 1250 mg/m2. The maximum dose intensity of the continuous fixed-dose schedule is 8750 mg/m2/week compared with 11,666 mg/m2/week for the standard dose and schedule (2500 mg/m2/day for 14 days every 21 days).

How do you take capecitabine for colon cancer?

Capecitabine Dosage 1 Usual Adult Dose for Colorectal Cancer. -The tablets should be swallowed whole with water within 30 minutes after a meal. 2 Usual Adult Dose for Breast Cancer. 3 Renal Dose Adjustments 4 Liver Dose Adjustments 5 Dose Adjustments. 6 Precautions. 7 Dialysis 8 Other Comments. 9 Further information.

Is capecitabine a first-line drug?

Capecitabine is currently approved by the FDA for use as first-line therapy in patients with metastatic colorectal cancer when single-agent fluoropyrimidine therapy is preferred. The drug is also approved for use as (1) a single agent in metastatic breast cancer patients who are resistant to both an …

Can capecitabine be combined with docetaxel for breast cancer treatment?

IN COMBINATION WITH DOCETAXEL (Metastatic Breast Cancer): Dose modifications of capecitabine for toxicity should be made according to the monotherapy schedule above.